Using a ½ inch cookie scoop, scoop out spoonfuls of mac and cheese and roll each one into a ball. Place the balls on a parchment-lined tray and set them in the freezer for 30 minutes.
Whisk together eggs and milk. Set aside.
In a separate bowl, stir together panko, parmesan cheese, salt, pepper, onion powder, and garlic powder.
Place the panko crumb mixture next to the air fryer and the egg mixture next to the crumb mixture. Once the bites are frozen, place the tray of mac and cheese bites next to the egg mixture.
Dip each mac and cheese ball in the egg mixture, roll it in the panko mixture, then place it in the air fryer.
Bake at 350°F for 10-15 minutes or until golden.